Six young Filipino doctors, returning to the Philippines after many years of specialized training in the United States, pooled their limited financial resources to set up in the City of Manila in 1965, a small laboratory with basic capabilities. This laboratory - the Medilab, was the beginning of a vision of comprehensive medical care that integrates a hospital and a medical insurance system. Under the dynamic leadership of Dr. Paulo C. Campos, this vision was made into a reality when University Physicians'​ Services, Inc., (UPSI) was organized on September 30, 1965.Backed financially by a non-medical group headed by Mrs. Soledad Lirio Dolor, UPSI established Medical Center Manila on July 29, 1967. What it had to offer was the best and most advanced medical and diagnostic equipment, and a staff of well-known and experienced consultants who are specialists in their respective fields.On August 15, 1967, the hospital was formally inaugurated as Medical Center Manila with Dr. Paulo C. Campos as its first Medical Director. The blessing was given by Rufino J. Cardinal Santos. Under the administration of the Sisters of St. Paul de Chartres, it opened with an initial capacity of 176 beds for adults and children and 24 bassinets in the Nursery. It was on August 15, 1982 when the MCM Extension was inaugurated and the blessing was given by Archbishop Jaime Cardinal Sin of Manila.On August 1, 1987, UPSI created the Hospital Management Services, Inc. (HMSI) as the legal entity that will own, manage and operate Medical Center Manila. In March 2013, Mount Grace Hospitals Inc. bought majority shares of HMSI and now operates and manages Medical Center Manila, rebranding it with its former nickname, ManilaMed.