The application of new technologies in medical science has been formed in Parseh Intelligent Surgical System Co. (PARSISS) Integrated Company in the Incubation Center of Medical Equipments and Devices since 2006. The preliminary studies of designing and manufacturing the navigation system, initiated with the presence of dominant professors from authentic universities of Iran along with the cooperation of many experts in the fields of Medical Engineering, Biomechanics, software and hardware engineering, Image Processing and other related fields. Finally in 2011 after 5 years continuous effort, various executing steps including design, implementation and Integration modules, advanced troubleshooting and optimization was completed and Parseh surgical navigation system with some better features than the similar foreign products , was presented successfully as a complete and integrated model of a navigation system in the surgery room.